The Pacific Coast Highway in California is an epic road trip adventure. The route between San Francisco and Santa Monica (or San Diego) includes the stunning Big Sur coast.
On the eastern side of the country, the Blue Ridge Parkway is an iconic road trip route bookended by Shenadoah and Great Smoky Mountains national parks.
Route 66 traverses seven US states, starting in Chicago, IL, and ending in Santa Monica, CA. The route is famous for the many roadside attractions and classic Americana.